*Source: https://www.years.co/en/years-ultimate* YEARS Ultimate® # Our most advanced preventive health program. YEARS Ultimate decodes your biology with research-grade diagnostics, year-round expert guidance, and unmatched insight. EUR 16,900 May vary depending on individual needs. - 30+ advanced diagnostic assessments in one day - Medical Genomics, Whole-Body MRI, Liquid Biopsy and more - Our most advanced lab panel with 230+ analyses - Monthly private coaching in nutrition, performance, and lifestyle - Cryopreservation of 70+ biological samples - Continuous monitoring, quarterly physician-led check-ins, and more Book YEARS Ultimate® Compare programmes “My visit to YEARS was an absolute surprise – preventive medicine here doesn’t feel like a typical doctor’s visit, but rather like a stay at a wellness hotel.” Lena Gercke Entrepreneur Decode Aging ## Your Ultimate® Journey ### Pre-Visit Consultation 30 Minutes | Concierge Intake Before your visit, our concierge team takes the time to understand your goals and priorities – tailoring your experience from the start. ### Ultimate® Clinic Visit 9 Hours | Full-Spectrum Diagnostics One day of 30+ research-grade diagnostics, spanning imaging, cardiovascular, metabolic, advanced molecular, and experimental testing. ### Risk Mapping & Strategic Planning 2 Weeks | In-depth Data Interpretation & Strategy Call Our physician team meticulously analyzes your data and reviews the findings with you in a focused strategy call. ### Monthly Coaching 1 Hour/Month | Private Coaching Nutrition, performance, sleep, and lifestyle optimization – guided by our specialists based on your real data. ### Ongoing Health Monitoring Quarterly | On Demand Healthspan Service Benefit from regular health insights through personalized, continuous monitoring for goal-oriented therapy. ### Annual Reassessment Yearly | Progress Review & Strategic Update Based on your first year's insights, our team recommends future assessments to track progress and refine your health trajectory. ## Diagnostics YEARS Core® The foundation of our diagnostics translates epidemiological research into clinical practice. 25+ assessments and 80+ biomarkers – the basis for strategies to support your healthspan. Cardiovascular Assessment High-Resolution Ultrasound AI-based Total Body Skin Mapping Comprehensive Lung Function Testing 3D Body Scan AI-Assisted Retinal Imaging Performance Diagnostics Neurocognitive & Mental Health Assessment Sensory Testing Bone Density Measurement Oral Glucose Tolerance Test (OGTT) Ultimate® Biomarker Panel The YEARS Ultimate® Panel analyzes 230+ biomarkers across 16 physiological systems, providing research-grade foundation for precision prevention and advanced longevity diagnostics. Blood and Gut Health Hormonal Regulation Immune Response Inflammation Markers Vitamin Levels Experimental Healthspan Allergy Screening Medical Genomics (Whole Genome + Whole Exome Sequencing) Using Whole Exome and Whole Genome Sequencing, we analyze over 170 risk genes for cancer, cardiovascular and metabolic diseases, plus pharmacogenomic profiles for more than 150 medications for proactive, personalized prevention. Genetic Risk Panel Pharmacogenomic Panel Predictive Neurodegenerative Panel Proprietary Whole Body MRI The YEARS Ultimate® MRI sequence enables high-resolution, radiation-free organ and tissue imaging that can support detection of hidden conditions (e.g. tumors, aneurysms, fatty liver or vascular anomalies). The YEARS whole-body MRI is used in an experimental, research-adjacent context and is interpreted accordingly. Multi-Organ Screen Cardiovascular Conditions Neurological Disorders Oncological Screening Liquid Biopsy for Multi-Cancer Detection TruCheck is an advanced, non-invasive blood test for early detection of over 70 tumors, with specificity of 96–99% and sensitivity of 65–89% (stage-dependent) in the published validation studies. YEARS deliberately uses liquid biopsy as a research-adjacent and experimental procedure: it complements established cancer screening and does not replace it. Liquid Biopsy (Multi-Cancer Detection) intelli TruBlood™ YEARS Performance Battery & Sports Science Analysis Led by our performance team: Advanced analysis of fitness, mobility, balance and muscle strength – for long-term performance. 3D Bodyscanning Motion Analysis Force Measurement Cardiovascular Fitness Personalized Plan Microbiomics Analysis of gut bacteria and fungi to reveal health risks. The report includes your microbial profile, biochemical markers and personalized recommendations. Microbial Diversity Gut Barrier Analysis Inflammation Markers Metabolic Health Personalized Nutrition Epigenetic and Non-Epigenetic Biological Clocks By integrating epigenetic and non-epigenetic markers, we analyze molecular patterns to assess aging processes at the cellular level and determine your biological age. Horvath Horvath Skin & Blood Hannum PhenoAge GrimAge DunedinPACE 7 Organ-Specific Ages ## Concierge Services YEARS Health Report All results are consolidated, visualized and clearly explained in your YEARS Health Report. Complex diagnostics become a clear picture of your body and potential risks. Personal Risk Profile Individual Health Strategy Progress Analysis (from Year 2) Personalized Prevention Plan Together with your physician, findings are translated into an individual prevention strategy. This plan is aligned with your goals and derives measures for long-term health and performance. Physician-Led Strategy Continuous Therapy Management Monitoring Check-ins: 3 Ultimate® includes three physician check-ins per year. Supported by individual controls and digital monitoring (e.g. CGM, blood tests or wearables), your health strategy is continuously adapted. In-Clinic Check-ins At-Home Blood Testing Adaptive Progress Monitoring Healthspan Coaching: Year-Round Monthly coaching with our specialists. Based on your current data, you receive personalized recommendations in nutrition, training, sleep and stress management with constant support and feedback. Fitness Coaching Nutritional Guidance Support Level: Year-Round With Ultimate® you benefit from permanent access to our Healthspan Concierge. Whether new findings, nutritional adjustments or training plan optimization – our team guides you every step of the way. 10h Healthspan Concierge YEARS Research Platform Access to innovative healthspan research, N-of-1 studies and tailored interventions – for early insights and potential participation in pioneering approaches. Supplements Advice Experimental Therapies N-of-1 Trials YEARS Biological Safe 70 samples from blood, stool and urine as well as living cells are cryopreserved. These biomaterials could – depending on scientific progress – support future developments in regenerative medicine, cell therapies or immunotherapies. Immune Cells Banking (PBMCs) Microbiome Liquid Biopsy (ccfDNA) Plasma Serum ## 10 Highlights of YEARS Ultimate® 1 / 10 ### YEARS Core® – The Foundation of Our Diagnostics Over 25 assessments and 80+ biomarkers YEARS Core was designed as a clinical translation of epidemiology. Drawing on evidence from the world's largest population studies, we reverse-engineered which diagnostics most reliably predict age-related disease. The result: 25+ functional examinations and 80+ biomarkers. Lab diagnostics · panel register ## Others quote a number. We list every marker. Full transparency instead of “230+”. Our Ultimate panel covers 233 individual biomarkers across 9 systems, listed here in full. Pick a program and the register shows what is included. 233 markers 9 systems 3 programs As of 07 · 2026 Core® 85 Evolve® 131 Ultimate® 233 All systems Basics & blood count 55 Liver 7 Kidney 5 Cardiovascular & lipids 30 Diabetes, coagulation & infection 20 Hormones & endocrinology 18 Vitamins, micronutrients & longevity 28 Immunology & autoimmune 26 Amino acid analysis 44 ### 01 Basics & blood count 55 / 55 + Albumin Calcium (ionisiert) Calcium, gesamt Chlorid Creatinkinase (CK) Eiweiß, gesamt Kalium LDH Lipase Magnesium Natrium Phosphat, anorg. Transferrin Leukozyten Erythrozyten Hämoglobin Hämatokrit MCV MCH MCHC Erythrozytenvert.-breite Thrombozyten Neutrophile Neutrophile absolut Lymphozyten Lymphozyten absolut Monozyten Monozyten absolut Eosinophile Eosinophile absolut Basophile Basophile absolut Granulozytenvorstufen Farbe (U) Trübung (U) pH (U) Spez. Gewicht (U) Blut (U) Leukozyten (U) Nitrit (U) Eiweiß (U) Glucose (U) Keton (U) Bilirubin (U) Urobilinogen (U) Ascorbinsäure (U) Albumin/Mikroalbumin (U) Creatinin (U) Präalbumin Albumin (Elektroph.) Alpha-1-Globulin Alpha-2-Globulin Beta-Globulin Gamma-Globulin Immunolog. Stuhltest (iFOBT) ### 02 Liver 7 / 7 + Alk. Phosphatase Bilirubin, direkt Bilirubin, gesamt Cholinesterase GOT (AST) GPT (ALT) Gamma-GT ### 03 Kidney 5 / 5 + Creatinin (enzymatisch) Cystatin-C Harnstoff Harnsäure Osmolalität ### 04 Cardiovascular & lipids 30 / 30 + Cholesterin, gesamt LDL-Cholesterin HDL-Cholesterin NON-HDL-Cholesterin Triglyceride Apolipoprotein B Lipoprotein (a) NT-proBNP Homocystein VLDL-Cholesterin Lp-PLA2 Oxidiertes LDL Fettsäuren, frei Omega-3-Index MR-proADM Creatinkinase-MB (CK-MB) Myoglobin α-Linolensäure (ALA) EPA DHA Linolsäure γ-Linolensäure Bishomo-γ-Linolensäure Arachidonsäure EPA/AA-Quotient Behensäure (C22:0) Lignocerinsäure (C24:0) Cerotinsäure (C26:0) Phytansäure Pristansäure ### 05 Diabetes, coagulation & infection 20 / 20 + HbA1c (NGSP) HbA1c (IFCC) Glucose (nüchtern) Glucose (+1h) Glucose (+2h) Insulin HOMA-Index Fibrinogen Quick (TPZ) aPTT Thrombinzeit (TZ) von-Willebrand-Diagn. HBc-Ak HBe-Ag HBs-Ag HBs-Ak/Anti-HB HBV-DNA quant. HCV-Ak HIV-1/2-Ak/p24-Ag TPHA (Syphilis) ### 06 Hormones & endocrinology 18 / 18 + TSH basal FT3 FT4 Cortisol DHEA-S Testosteron, gesamt Testosteron, frei SHBG Östradiol FSH LH Prolactin IGF-1 ACTH Aldosteron PTH, intakt HGH/Wachstumshormon PSA, gesamt ### 07 Vitamins, micronutrients & longevity 28 / 28 + Vitamin D 25-OH Vitamin B12 Folsäure Ferritin Eisen Vitamin A/Retinol Vitamin B1 Vitamin B6 Vitamin E Vitamin K1 Vitamin K2 Jod, gesamt Selen Zink Coenzym Q10 Nicotinamid Adiponectin Leptin Beta-CrossLaps (CTX) CDT TMAO GDF-15 Quotient pTau217 exp Amyloid beta 1-42 exp Cotinin 3-OH-Cotinin Nicotin Anabasin ### 08 Immunology & autoimmune 26 / 26 + CRP high sensitive Interleukin-6 IgG Turbidimetrie IgA Turbidimetrie IgM Turbidimetrie Immunglobulin E (IgE) Antinukleäre-Ak (ANA) CCP-Ak tTG2-Ak IgA Rheumafaktor IgM c-ANCA p-ANCA Multiplex Allergietest (ALEX2) Lymphozyten, gesamt T-Lymphozyten (CD3+) T-Helferzellen (CD4+) T-Suppressorz. (CD8+) T-Zell-Ratio (CD4/CD8) B-Lymphozyten (CD19+) NK-Zellen IgG 1 IgG 2 IgG 3 IgG 4 IgA 1 IgA 2 ### 09 Amino acid analysis 44 / 44 + Alanin Arginin Asparagin Aspartat Cystin Glutamin Glutamat Glycin Histidin Isoleucin Leucin Lysin Methionin Phenylalanin Prolin Serin Threonin Tryptophan Tyrosin Valin 1-Methylhistidin 3-Methylhistidin Adenosylhomocystein Allo-Isoleucin α-Aminoadipinsäure α-Aminobuttersäure Anserin Beta-Alanin β-Aminoisobuttersäure Carnosin Citrullin Cystathionin Ethanolamin GABA Hydroxylysin Hydroxyprolin Ornithin Phosphoethanolamin Phosphoserin Pipecolinsäure Saccharopin Sarcosin Sulfocystein Taurin ### 10 Additional procedures Ultimate only · not blood markers + Whole-Genome-Sequencing Whole-Exome-Sequencing Pharmakogenetik Ganzkörper-MRT exp Liquid Biopsy / TruCheck exp Programs are cumulative: Evolve includes all Core markers, Ultimate all Evolve markers. “EXP” marks experimental procedures still under research — details in the transparency chapter. ## Frequently asked questions about YEARS Ultimate What distinguishes Ultimate from Evolve? + Ultimate includes everything from Evolve and adds four areas: medical genomics, epigenomics, microbiome analysis and experimental longevity markers. The number of laboratory biomarkers rises from around 120 to roughly 230. The second difference is the level of care. Instead of one check-in per year there are three, and you get a dedicated health manager as your point of contact, plus concierge services for coordinating follow-up appointments. The examination day takes around nine hours, as with Evolve. Ultimate costs 16,900 euros. The difference therefore lies less in any single test than in the shift from a snapshot to year-round medical oversight. What does medical genomics actually deliver? + Genetic analysis reveals predispositions that blood values cannot show. Three areas are practically relevant: hereditary cancer risks such as BRCA variants, cardiovascular predispositions such as familial hypercholesterolaemia, and pharmacogenetics, meaning how your body metabolises certain medications. This information changes something concrete, because it affects screening intervals and medication choices. The limitation belongs with it: a genome is not a prognosis. Most variants shift probabilities slightly without determining anything, and many findings are of unclear significance. We therefore always discuss genetic results medically, partly because they can affect relatives and partly because German genetic diagnostics law requires counselling. You decide in advance which categories of finding you want to be told about at all. What does epigenetic age tell you — and what does it not? + Epigenetic clocks estimate a biological age from the methylation pattern of your DNA. Across large study populations these estimates do correlate with disease risk and mortality, and that is well established. The jump from population to individual is exactly where the market regularly overpromises. Different clocks return different values for the same sample, repeat measurement precision is limited, and there is so far no evidence that a lowered epigenetic age actually leads to a longer life. We use the value as a supplementary parameter to track over time alongside robust markers, not as a figure you should base decisions on. What does the health manager do? + The health manager is your constant point of contact across the year, so you do not have to explain your situation from scratch every time. In practice they handle three things. They coordinate appointments and follow-up diagnostics, including those with external specialists when a finding needs further investigation. They track the prevention plan and get in touch when a follow-up value is due, rather than waiting for you to remember. And they are the route to your treating physician for questions between appointments. The health manager does not replace medical judgement; clinical decisions stay with the specialist. Their job is to keep the plan from stalling in everyday life. Who is Ultimate genuinely worth it for? + Ultimate is the most comprehensive program and at 16,900 euros also the most expensive, so here is a clear framing. It fits when two things come together: an actual medical reason for the additional depth, such as a relevant family history or a complex set of existing findings, and a wish for year-round guidance rather than a one-off measurement. If you mainly want to know where you stand, Core or Evolve answers that without the additional diagnostics. More markers do not automatically mean more clarity; they also mean more findings of unclear significance. If Ultimate is not right for you, we will say so in the free intro call, before you book. ## An investment to protect, preserve, and enhance your most valuable asset: your health. Book YEARS Ultimate® Discover our other programmes