Knowledge Hub

Everything on longevity, prevention and diagnostics — in one place.

A structured index of all guides, landing pages and blog articles from YEARS: from check-up programs through cancer screening to biomarkers, nutrition, and current research.

Check-ups & Diagnostics

Comprehensive preventive programs and diagnostics across all ages and life stages.

From the Blog

Longevity Fundamentals

What longevity medicine is, which programs exist, what they cost, and their scientific foundations.

From the Blog

Hallmarks of Aging

The twelve biological processes research associates with ageing. Mechanism, evidence and limits of each — a framework, not a diagnostic tool.

Pages & Guides

The hallmarks of aging at a glance

Where the model comes from, what it delivers and where it reaches its limits.

Genomic instability

DNA is damaged thousands of times a day. Whatever repair misses remains as a mutation.

Telomere attrition

Chromosome ends shorten with every division. Longer is not automatically better.

Epigenetic alterations

It is not the DNA text that changes but which passages get read. This is the basis of the best-validated ageing clocks.

Loss of proteostasis

Proteins must be folded exactly right to work. The quality control for this declines with age.

Disabled macroautophagy

Cells break down their own components and reuse them. This recycling loses capacity with age.

Nutrient sensing

The pathways that distinguish abundance from scarcity are the best-studied control point in ageing research.

Mitochondrial dysfunction

The cell’s power plants lose efficiency. The familiar explanation via free radicals turned out to be wrong.

Cellular senescence

Cells stop dividing permanently but do not die. From this in-between state they reshape their surroundings.

Stem cell exhaustion

Tissue reserves for renewal shrink and slow down. The cells themselves are not always the problem.

Intercellular communication

Ageing is not only a process inside single cells. The signals between them shift systematically.

Chronic inflammation

A low-grade constant signal without infection. The most measurable and most over-interpreted hallmark.

Dysbiosis

Gut flora shifts with age. What counts as a healthy microbiome cannot yet be defined.

From the Blog

Cancer Screening & Early Detection

Modern cancer prevention methods from imaging to multi-cancer screening and liquid biopsy.

From the Blog

Nutrition & Lifestyle

Evidence-based nutrition, exercise, sleep and mental health as the foundation of long healthy years.

From the Blog

Biomarkers & Lab Values

The key biomarkers and what they reveal about your biological age, cardiovascular and metabolic health.

From the Blog

Genetics & Genomics

Panel, array, exome, genome: which methods exist, which findings carry a consequence, and what German genetic diagnostics law requires.

From the Blog

Comparisons & Alternatives

How do longevity providers compare? Transparent overview of programs, prices and scope.

From the Blog

Research & Evidence

Current studies and scientific foundations behind preventive medicine and longevity.

From the Blog

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